The state of Mississippi is named after the Mississippi River.

Mississippi is the only U.S. state named directly after the Mississippi River, which forms much of its western boundary. The name “Mississippi” originates from Native American words meaning "great river" or "father of waters," reflecting the river’s significance. The river’s influence is evident in the state’s culture, economy, and geography, supporting agriculture, transportation, and trade. The Mississippi River's legacy is deeply woven into the state's history and identity.