The type of grassland common in the southern part of the Interior Plains is Tallgrass prairie.

Tallgrass prairie is distinguished by its towering grasses, which can grow as tall as six feet. This ecosystem flourishes in regions with moderate rainfall and is renowned for its rich biodiversity, featuring numerous wildflowers and diverse wildlife. In the past, tallgrass prairies spanned extensive regions of the central United States, particularly in parts of the southern Interior Plains. These grasslands are vital for agriculture, grazing, and maintaining the ecological health of the area.