The Ohio and Mississippi Rivers meet near Cairo, Illinois, forming a significant river confluence.

Near Cairo, Illinois, the Ohio River joins the Mississippi River, creating one of the most important river confluences in the U.S. This meeting of two major rivers enhances the flow and volume of the Mississippi, significantly impacting navigation, commerce, and flood management downstream. The Ohio River, carrying waters from the eastern U.S., contributes a considerable volume, making this confluence a strategic point for trade and ecological diversity within the Mississippi River Basin.