The Colorado River forms part of the southern boundary of the Sonoran Desert.

The Colorado River acts as a natural boundary for the Sonoran Desert, flowing through the southwestern United States and into northern Mexico. This vital river provides a lifeline for the desert's ecosystems, supporting plant and animal life in an otherwise arid region. Additionally, it supplies water for agriculture, human settlements, and wildlife along its course. The Colorado River’s proximity shapes the geography and biodiversity of the southern edge of the Sonoran Desert, making it an essential resource in a landscape characterized by extreme heat and minimal rainfall.