The Tennessee River runs through the Appalachian Mountains, flowing through several states in the region.

The Tennessee River is one of the major rivers that runs through the Appalachian Mountains, particularly in the southeastern United States. Originating in the Appalachian region in East Tennessee, the river flows through parts of Tennessee, Alabama, Mississippi, and Kentucky, creating a vital waterway for the region. It is a key feature of the river basin and has played an important role in the history, economy, and transportation routes of the Appalachian area. The river also passes through scenic areas, providing access to recreational activities such as boating, fishing, and hiking in the surrounding mountains.