The river that cuts through the Appalachian Mountains is the Potomac River.

The Potomac River flows through the Appalachian region, originating in West Virginia and cutting through the mountains before reaching the Chesapeake Bay. It serves as a significant geographical feature, providing not only natural beauty but also vital resources for recreation, transportation, and water supply. The river's journey through the Appalachians contributes to the scenic landscapes and ecosystems found in the area.