The Great Smoky Mountains National Park is located in the Appalachian region and is one of the most famous national parks in the U.S.

The Great Smoky Mountains National Park, located along the border of North Carolina and Tennessee, is part of the Appalachian Mountains. It is known for its biodiversity, mist-covered mountains, and scenic beauty. The park is a UNESCO World Heritage Site and is one of the most visited national parks in the United States. The park's ecosystems range from temperate deciduous forests to high-altitude alpine areas, supporting diverse wildlife, including black bears and salamanders. The Great Smoky Mountains are a significant destination for outdoor activities like hiking, camping, and wildlife viewing.