The Chihuahuan Desert is most similar to the Sonoran Desert due to shared climate and plant species.

The Chihuahuan Desert is geographically close to the Sonoran Desert and shares many similarities, including its arid climate, hot temperatures, and seasonal rainfall patterns. Both deserts feature cacti, yucca plants, and thorny shrubs as dominant vegetation. They also host similar wildlife, including jackrabbits, lizards, and coyotes. While the Sahara Desert and Atacama Desert are both arid, they are more distinct due to different climatic conditions and ecosystems. The Great Basin Desert, located to the north, has a cooler, more temperate climate compared to the Sonoran and Chihuahuan deserts.