The natural resource that is abundant in the Interior Plains region is Oil.

The Interior Plains are rich in fossil fuel deposits, particularly oil and natural gas. These resources have been extensively extracted in several states and provinces across the region, contributing significantly to the local and national economies. The presence of oil fields, particularly in areas like the Bakken Formation in North Dakota and Saskatchewan, makes the Interior Plains a crucial area for energy production. Additionally, the region's geology supports the formation of oil reserves, leading to ongoing exploration and development in the energy sector.