The Appalachian Mountains primarily feed the Mississippi River through its tributaries.

The Appalachian Mountains play a key role in feeding the Mississippi River through their numerous tributaries. Rivers like the Tennessee, Ohio and Cumberland originate in these mountains, ultimately flowing into the Mississippi River. These waterways contribute to the river's volume and significantly affect its flow and ecosystem. The Appalachian region, with its rich biodiversity and varied terrain, helps shape the overall health and function of the Mississippi River system.