The Wasatch Mountains form the eastern boundary of the Great Basin, marking a distinct geographical division.

The Great Basin is a large, arid region that is bordered by several mountain ranges. To the east, it is primarily defined by the Wasatch Mountains, which run through the state of Utah. These mountains separate the Great Basin from the more humid regions to the east, including the Rocky Mountains. The Wasatch Range is crucial in shaping the basin's climate and water flow patterns, and it plays an important role in defining the Great Basin’s unique ecosystem.