The major hurricane that made landfall on the Gulf Coast in 2005, causing widespread devastation, was Hurricane Katrina.

Hurricane Katrina was one of the most devastating hurricanes in U.S. history. It made landfall on August 29, 2005, causing catastrophic damage, particularly in New Orleans, Louisiana. The storm caused extensive flooding, infrastructure damage, and loss of life. It was later followed by Hurricane Rita, but Katrina remains the most significant event of that year in terms of destruction.