The major highway that runs through the Basin and Range Province is Interstate 15.

Interstate 15 is a key north-south highway that traverses the Basin and Range Province, connecting several important cities and regions. It begins in Southern California, passes through Nevada, and continues into Utah, making it a vital route for both commerce and travel. The highway facilitates access to various attractions and economic hubs in the region, including Las Vegas, which is a significant destination for tourism and entertainment. I15 also serves as an essential corridor for transporting goods and resources throughout the Basin and Range Province, contributing to its economic development.