Knoxville, Tennessee, is located just to the west of the Appalachian Mountains, near the foothills of the Smoky Mountains.

Knoxville, Tennessee, is situated just west of the Appalachian Mountains, specifically near the foothills of the Great Smoky Mountains. It serves as a key gateway to the Appalachian region and the Great Smoky Mountains National Park, one of the most visited national parks in the U.S. Knoxville has a rich cultural heritage, with many historic landmarks, museums, and a thriving arts scene. The city's location makes it a popular destination for outdoor activities such as hiking, fishing, and camping, offering easy access to the scenic beauty of the Appalachian Mountains. As a regional economic and educational center, it is home to the University of Tennessee and plays an important role in the state's economy.