The historic trading route that passed through the Coastal Plains is  The Camino Real.

The Coastal Plains were traversed by the Camino Real, a historic trade route that was essential to regional transit and commerce. This route, which was established during the Spanish colonial era, allowed the flow of people, products, and ideas between significant communities like San Antonio and New Orleans. The Coastal Plains' rich heritage is a result of the Camino Real's facilitation of the interchange of cultural influences. As a vital conduit for trade, it influenced the region's economic climate, fostering the development of nearby settlements and leaving a lasting mark on the area's history.