Cairo, Illinois, is located at the confluence of the Mississippi and Ohio River.

Cairo, Illinois, is a significant city situated at the confluence of the Mississippi and Ohio Rivers, making it a strategic point for trade and transportation. This unique location has historically contributed to Cairo's importance as a shipping hub, facilitating the movement of goods between different regions. The city's rich history and diverse culture reflect its role as a melting pot of influences from various communities, enhanced by its picturesque riverfront views and vibrant economy.