The city in the Southwest famous for its proximity to the Grand Canyon is Flagstaff.

Flagstaff, located in northern Arizona, is one of the closest major cities to the Grand Canyon, just about 80 miles south of the park. It serves as a popular gateway for visitors heading to the Grand Canyon, offering accommodations, dining, and other services. Flagstaff is also known for its scenic mountain views, outdoor activities, and vibrant arts scene, making it a perfect base for exploring the natural beauty of the region, including the Grand Canyon.