The Appalachian state's economy was largely built around tobacco farming in North Carolina.

Tobacco cultivation has long been the foundation of North Carolina's economy and has contributed significantly to the state's development over the ages. The Appalachian region's rich soil and temperate climate gave it the perfect place to cultivate tobacco, which became a significant economic force. In addition to influencing the state's agricultural sector, tobacco production sparked the growth of other sectors including processing and manufacturing. Tobacco's economic significance has diminished over time as a result of changing regulations and demands, but it still has a big impact on North Carolina's history and economics, especially in the rural areas where it was once dominant.