The creek that played a significant role in the Battle of Antietam is Antietam Creek.

This waterway served as a strategic landmark throughout the battle, influencing troop movements and the positioning of artillery. Its banks became the site of fierce fighting, particularly as Union and Confederate forces clashed over control of key fords and bridges. The creek also contributed to the high casualty rate, as soldiers attempted to cross under heavy fire. The name "Antietam" has since become synonymous with the battle, remembered for the bloodshed and tactical maneuvers that unfolded along its banks on September 17, 1862.