Catfish are the most commonly harvested fish species in the Mississippi River.

Catfish are abundant in the Mississippi River and are a primary species harvested in its waters. These fish are well-suited to the river's warm, muddy environment, making them a popular target for commercial and recreational fishing. The Mississippi River’s rich ecosystem supports a thriving catfish industry, with species like channel catfish and blue catfish being particularly important for both local consumption and nationwide distribution.