The Battle of Antietam had a significant psychological impact on soldiers, particularly in creating PTSD.

The ferocity of the battle, marked by devastating injuries and overwhelming losses, left numerous soldiers struggling with the traumatic consequences. The chaos, the loss of fellow soldiers, and the grim truths of warfare created enduring emotional and psychological wounds. Although some soldiers experienced a brief uplift in morale from the Union's tactical success, the extreme violence of the conflict also resulted in profound psychological turmoil that would linger for many years.