The Mississippi River plays a crucial role in the agriculture of the Interior Plains, often referred to as North America's "breadbasket."

This major river system provides essential irrigation, supporting the growth of key crops such as corn, soybeans, and wheat. Its fertile floodplains enrich the soil, making the region highly productive for farming. Additionally, the river serves as a vital transportation route, allowing farmers to efficiently move their goods to markets. The interplay of water, fertile land, and agricultural activity has established the Interior Plains as a significant contributor to the nation's food supply and economy.