The primary threat to the Sonoran Desert's pronghorn population is habitat loss due to human development and land encroachment.

The Sonoran pronghorn faces significant threats from habitat loss and fragmentation caused by human encroachment, including agricultural development, urban expansion, and infrastructure projects. These activities disrupt their natural environment, reducing the available space for the pronghorn to roam, find food, and breed. Although climate change and drought also pose challenges, habitat loss is considered the most pressing issue for the survival of this endangered species. Conservation efforts aim to protect their habitats and mitigate human impact to ensure a stable pronghorn population.