The largest city in the Sonoran Desert is Phoenix.

Phoenix, the capital of Arizona, is the largest city located in the Sonoran Desert, with a population of over 1.6 million people. Situated at the heart of the desert, Phoenix experiences an arid climate with extremely hot summers and mild winters, typical of desert regions. Despite its dry environment, the city has grown into a bustling urban center, supported by a strong economy, diverse industries, and water resources like the Salt River. Phoenix's modern infrastructure and status as a cultural and economic hub make it a key city in the southwestern United States.