The largest city in the Mojave Desert region is Las Vegas.

Las Vegas, located in southern Nevada, is the largest city in the Mojave Desert region. Famous for its vibrant entertainment scene, including casinos, hotels, and resorts, the city attracts millions of visitors each year. Despite the harsh desert climate, Las Vegas has become a major urban center, thriving due to tourism, conventions, and entertainment industries. It is also known for its iconic landmarks like the Las Vegas Strip. Over the years, the city has expanded rapidly, making it a key economic and cultural hub in the southwestern United States.