The industry that relies heavily on the Mississippi River for transportation is agriculture.

Agriculture is the primary industry that depends on the Mississippi River for transportation, utilizing the river's extensive network to move goods efficiently. The river serves as a vital artery for shipping crops such as corn, soybeans, and wheat from the Midwest to domestic and international markets. This transportation route significantly reduces shipping costs and enhances supply chain efficiency. The Mississippi River plays a crucial role in supporting the agricultural economy, benefiting farmers and consumers alike.