The Mississippi River is part of the Continental Divide of the Americas, influencing water flow toward the Gulf of Mexico.

The Mississippi River is situated inside America's Continental Divide, a significant natural watershed border. Water flowing into the Pacific Ocean separates from water flowing toward the Atlantic and Gulf of Mexico by this split. The Mississippi River flows into the Gulf of Mexico as part of this split, influencing the drainage basin, ecosystem, and neighboring areas in terms of water flow and management.