The Interior Plains region is home to the major Canadian city of Calgary.

Calgary, located in Alberta, is a major Canadian city situated within the Interior Plains region. Known for its proximity to the Rocky Mountains, Calgary serves as an economic and cultural hub, with a diverse economy that includes agriculture, energy, and technology. The city's location on the plains contributes to its favorable conditions for ranching and farming, aligning with the region's agricultural activities. Calgary is also famous for its annual Calgary Stampede, which celebrates its Western heritage.