The confluence of the Missouri River and Mississippi River is located near St. Louis.

The confluence of the Missouri River and Mississippi River occurs just north of St. Louis, Missouri. This significant geographical point marks the meeting of two major waterways, which have played crucial roles in the history and economy of the region. The confluence has been vital for trade, transportation, and settlement, facilitating commerce and cultural exchange. Today, it remains an important landmark, symbolizing the interconnectedness of the rivers and their impact on American development.