The Appalachian region has a high prevalence of obesity, which is linked to factors like poverty, limited access to healthcare, and unhealthy dietary habits.

Obesity is a significant health concern in the Appalachian region, driven by socioeconomic factors, limited physical activity opportunities, and cultural dietary preferences high in calorie-dense foods. This condition contributes to other chronic health issues such as diabetes, cardiovascular diseases, and hypertension, creating a cycle of poor health outcomes. While cardiovascular diseases are also prevalent, obesity is a root cause that exacerbates many other conditions. Efforts to address these issues include promoting education, improving healthcare access, and encouraging healthier lifestyles in the region.