After Alexander's death in 323, anti-Macedonian feelings drove Aristotle out of Athens, and he ed to Chalcis in Euboea, where he died in 322.

In 323 BC, following anti-Macedonian reactions in Athens, Aristotle took refuge in the city of Chalcis, which was located on the island of Euboea in Greece. According to tradition, when Aristotle left Athens, he is said to have declared that he was saving the Athenians from sinning twice against philosophy, in reference to the execution of Socrates, who was considered by many to be the greatest philosopher of his time. Aristotle remained in Chalcis until his death in 322 BC. During this time, he continued his philosophical work and is said to have founded a philosophical school known as the Lyceum. The Lyceum was a center for philosophical study and research, and it became an important hub of intellectual activity in the ancient world.