The Mississippi River significantly impacts the U.S. economy through transportation and trade.

The Mississippi River serves as a vital artery for transportation and trade, facilitating the movement of goods across the United States. It supports a network of barges and cargo ships, enabling efficient and cost-effective transport of agricultural products, raw materials, and manufactured goods. This waterway connects interior states to global markets, fostering economic growth in industries like agriculture, manufacturing, and tourism. The river's role is crucial for sustaining local economies and promoting regional commerce.