The major river that flows through the Coastal Plains is the Mississippi River.

As one of the longest rivers in the United States, it plays a crucial role in shaping the geography and ecology of the region. The river runs through various states, including Minnesota, Wisconsin, Iowa, Illinois, Missouri, Kentucky, Tennessee, Arkansas, Mississippi, and Louisiana, ultimately emptying into the Gulf of Mexico. The Mississippi River is vital for agriculture, providing irrigation to surrounding farmlands and supporting diverse ecosystems along its banks. It also serves as an essential transportation route for shipping goods and connecting various inland regions to the Gulf Coast. Additionally, the river’s floodplain is rich in biodiversity, making it a key habitat for numerous plant and animal species.