Native American ruins are significant cultural landmarks in the Sonoran Desert, reflecting the rich history of indigenous peoples in the region.

The Sonoran Desert is home to several important Native American cultural sites, with ruins that offer a glimpse into the lives of ancient desert-dwelling communities. Pueblo ruins, such as those of the Hohokam and Tohono O'odham peoples, are scattered throughout the region. These ruins include remains of homes, storage areas, and ceremonial structures, providing valuable insights into the sophisticated agricultural practices and spiritual beliefs of these tribes. Sites like Casa Grande Ruins National Monument and Tucson's Mission San Xavier del Bac serve as reminders of the cultural significance of the Sonoran Desert's early inhabitants.