The desert tortoise is an endangered species in the Mojave Desert, primarily due to habitat destruction, disease, and human activities.

The desert tortoise (Gopherus agassizii) is native to the Mojave and Sonoran Deserts and is a keystone species, meaning its presence significantly affects the ecosystem. These tortoises are threatened by habitat loss due to urbanization, off-road vehicle use, and energy projects. Additionally, diseases like Upper Respiratory Tract Disease and predation by ravens have contributed to their decline. Listed under the Endangered Species Act, conservation efforts focus on habitat protection, minimizing human interference, and breeding programs to increase their population. Other species like the black widow spider, mountain goat, and bobcat are not endangered in this region.