Sagebrush is the dominant plant species in the Great Basin, covering large areas of the region's landscapes.

The Great Basin is primarily characterized by arid and semi-arid conditions, with its vegetation adapted to survive in dry environments. Sagebrush, particularly the species Artemisia tridentata, is the most common and iconic plant in the region. It is a hardy shrub that can tolerate the low rainfall and harsh conditions typical of the Great Basin. Sagebrush ecosystems are crucial habitats for many species of wildlife and are a defining feature of the region's vegetation. Other plants like cacti and juniper trees are also found, but sagebrush is the most prevalent across the basin.