The largest river in the Great Basin is the Humboldt River.

The Humboldt River, stretching about 330 miles through northern Nevada, is the longest and largest river within the Great Basin. It originates in the northern part of Nevada and flows westward before reaching the desert. Unlike rivers in other regions, it does not drain into the ocean but ends in a dry lakebed. Historically, the Humboldt River was vital for Native American tribes and settlers crossing the region. Its waters provide essential irrigation and support agriculture in an otherwise arid area, making it a key geographical feature of the Great Basin.