Tobacco has been a historically significant crop in the Appalachian region, serving as a key agricultural product and economic driver for many Appalachian communities.

Tobacco cultivation has deep historical roots in the Appalachian region, particularly in states like Kentucky, Tennessee, and Virginia. The region's fertile soil and moderate climate were ideal for growing tobacco, which became a major cash crop in the 18th and 19th centuries. It was integral to the local economy, contributing to trade and export. However, as awareness of the health risks associated with tobacco use grew, the industry faced a decline. Despite this, tobacco farming still holds cultural and historical significance in the region, and many farms have diversified into other crops or agritourism to adapt to changing markets.