The Mississippi River runs through much of the Midwest region, serving as a major geographical and historical landmark.

The Mississippi River is one of the longest and most important rivers in North America, flowing through the heart of the Midwest region. It begins in Minnesota and travels southward, passing through states like Wisconsin, Iowa, Illinois, Missouri, and others before emptying into the Gulf of Mexico. The river has played a crucial role in the development of the Midwest, facilitating transportation, trade, and settlement. Its influence on agriculture, industry, and culture in the region remains significant to this day.