The majority of U.S. freshwater fish production comes from the Mississippi River Basin, particularly from aquaculture farms in the region.

The Mississippi River Basin is a hub for freshwater fish farming, with species like catfish dominating production. States such as Mississippi, Alabama, and Arkansas are leading producers, leveraging the basin's abundant water resources and fertile land for aquaculture. This region's warm climate and suitable water quality make it ideal for raising freshwater fish. Catfish farming, in particular, is a major industry here, contributing significantly to the U.S. seafood market. The basin’s role in freshwater aquaculture supports regional economies while meeting the growing demand for sustainably farmed fish.