The Mississippi River played a significant role in the Civil War, serving as a vital strategic route for both Union and Confederate forces.

During the Civil War, the Mississippi River was a key strategic asset, dividing the Confederate South from the Union-controlled North. Control of the river was essential for transportation, supply lines, and military movements. The Union's victory in the Battle of Vicksburg in 1863, which gave them control of the river, was a turning point, helping to split the Confederacy and weaken its ability to fight.