Fifteen states are part of the Mississippi River basin, which spans a large region across the United States.

From the Mississippi River's headwaters in Minnesota to its mouth in Louisiana, the Mississippi River basin spans 15 states. Parts of the Midwest, South, and Central U.S. are included in these states. The basin is one of the biggest and most significant basins in North America, with a wide area and many tributaries. In these states, the river basin is vital to transportation, agriculture, and wildlife habitats.