The Mississippi River meets the Gulf of Mexico in the U.S. state of Louisiana.

The Mississippi River flows into the Gulf of Mexico in the state of Louisiana, creating a vital estuary that supports diverse ecosystems. This confluence is crucial for both the environment and the economy, facilitating commercial shipping and fishing industries. Louisiana's unique geography and rich cultural heritage are influenced by the river's presence, with cities like New Orleans benefiting from the river's transportation routes and resources, making it an essential hub for trade and tourism.