The Mississippi River flows through or borders 10 U.S. states.

The Mississippi River traverses or borders 10 U.S. states: Minnesota, Wisconsin, Iowa, Illinois, Missouri, Kentucky, Tennessee, Arkansas, Mississippi, and Louisiana. This significant reach underscores the river's role as a vital waterway in the central United States, serving as a natural boundary for several states. The river influences local economies and ecosystems, supporting transportation, agriculture, and tourism, while enriching the cultural heritage of the communities that line its banks.