A major cave system located in the Appalachian Mountains is Mammoth Cave.

Mammoth Cave, located in Kentucky, is the longest cave system in the world, with over 400 miles of explored passageways. It is known for its impressive geological formations, unique ecosystems, and rich history. Designated as a national park, Mammoth Cave attracts numerous visitors each year who come to explore its vast underground chambers and learn about its natural and cultural significance. The cave system's intricate passages and diverse habitats make it a remarkable feature of the Appalachian region.