Tobacco has been one of the primary crops grown in the Appalachian region.

It was a significant cash crop for many farmers in states like Kentucky, Tennessee, and Virginia. The Appalachian region's climate and soil were well-suited for tobacco cultivation, and it became a key part of the agricultural economy, especially in rural areas. Tobacco farming helped shape the culture and traditions of Appalachian communities for generations, contributing to the region’s economic development and agricultural practices.